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Sucralfate - Benefits, dosage and side effects

Sucralfate or sucralfate is a drug to treat gastric ulcers, duodenal ulcers, or chronic gastritis. Sucralfate is available in the form of tablets, caplets, and suspensions that should only be used with a doctor's prescription.



Sucralfate works by sticking to the injured part of the stomach or intestine. This drug protects the wound from stomach acid, digestive enzymes, and bile salts. That way, sucralfate prevents the wound from getting worse and helps the wound heal faster.


Sucralfate trademarks: Dopepsa, Episan, Episan 500, Eficap, Erpepsa, Gitafat, Inpepsa, Kalpepsa, Kralix, Lipepsa, Lanpepsa, Mucogard, Mucifat, Molafate, Nucral, Neciblok, Pepco, Peptifate, Propepsa, Profat, Peptovell, Sulfatgen , Sucralbat, Sucralfate, Troflat, Taxilan, Ulsafate, Ulcera, Ulsidex, Ulcron, Ulcumaag


Warning Before Taking Sucralfate

Sucralfate should not be taken carelessly. There are several things that must be considered before using this drug, including:


Do not take sucralfate if you are allergic to this drug. Always tell your doctor about any allergies you have.

Tell your doctor if you have diabetes or kidney disease, especially chronic kidney failure that requires dialysis.

Tell your doctor if you have difficulty swallowing (dysphagia) or have recently had a medical procedure that makes it difficult for you to swallow and requires a feeding tube, such as a tracheostomy or endotracheal intubation.

Consult a doctor about the use of sucralfate in the elderly or patients who use a feeding tube.

Do not give sucralfate to children without consulting a doctor first.

Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.

Talk to your doctor about using sucralfate if you are taking other medications, including supplements and herbal products, to anticipate drug interactions.

See your doctor immediately if you have an allergic reaction or overdose after taking sucralfate.

Sucralfate Dosage and Use Rules

The following are the dosages of sucralfate for adult patients based on their intended use:


Goal: Overcoming chronic gastritis, gastric ulcer, and duodenal ulcer


The dose is 1 gram, 4 times a day (every meal and at bedtime); or 2 grams, 2 times a day (at breakfast and at bedtime), for 4–8 weeks

Goal: Prevent duodenal ulcer recurrence


The dose is 1 gram, 2 times a day (before breakfast and before bed). If a gastric ulcer, chronic gastritis, or duodenal ulcer has not healed, treatment is given for up to 12 weeks.

Objective: Prevent gastrointestinal bleeding in intensive care in hospital


The dose is 1 gram, 6 times a day. The maximum dose is 8 grams per day.

How to Take Sucralfate Correctly

Follow the doctor's advice and read the information listed on the drug packaging label before using sucralfate. Do not increase or decrease the dose without consulting your doctor first.


Sucralfate should be taken on an empty stomach, ideally 1 hour before meals or 2 hours after meals. Swallow the sucralfate tablet or caplet with the help of a glass of water.


If you are taking sucralfate in suspension, shake the bottle before drinking. Use the measuring spoon provided in the medicine package to take sucralfate suspension so that the dose of medicine you take is right


Consume sucralfate regularly at the same time every day to get maximum benefits. If you forget to take sucralfate, do it immediately if the break with the next schedule of use is not too close. If it is near, ignore the missed dose and do not double the next dose.


Do not stop taking sucralfate even if your condition has improved, unless advised by your doctor. Perform control according to the schedule given by the doctor, so that the condition and response to therapy can be monitored.


If you have or are currently suffering from diabetes, while on treatment with sucralfate, you may be asked to have your blood sugar checked regularly.


Store sucralfate in a dry place away from direct sunlight. Keep out of reach of children.


Sucralfate Interactions with Other Drugs

Interactions that can occur if sucralfate is used together with certain drugs are:


Decreased absorption and effectiveness of digoxin, quinidine, ketoconazole, sulpiride, levothyroxine, phenytoin, tetracycline antibiotics, fluoroquinolones antibiotics, warfarin, theophylline, dolutegravir, or H2 antagonist drugs

Increased risk of aluminum poisoning when used with vitamin D or aluminum-containing antacids

Give a gap of at least 2 hours if you want to take other drugs, because sucralfate can affect the absorption of drugs into the body. Avoid taking antacids 30 minutes before or after taking sucralfate.


Sucralfate Side Effects and Dangers

Side effects that may arise after taking sucralfate are:


  • Constipation or diarrhea

  • Dry mouth

  • Stomach ache

  • Nausea, vomiting, flatulence, or indigestion

  • Dizzy

  • Drowsiness

  • Insomnia

  • Headache

  • Back pain


Check with your doctor if the side effects above don't go away or get worse. Immediately see a doctor if you have an allergic reaction to the drug or a more serious side effect, such as muscle aches, bone pain, stomach cramps, vomiting, inability to pass gas, or inability to have a bowel movement.


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